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butabarbital will reduce the extent or effect of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Impact of coadministering a solid CYP3A4 inducer with fedratinib has not been examined.butabarbital will minimize the extent or influence of levamlodipine by affecting hepatic/intestinal enzyme CYP3A4